The reigning African champions dominated the game thanks to a double from Bilal Bekkali, and goals from Hamza Bouizane, Saad Knia and Anas Ariane.
The opposing team's three goals were scored by Davron Chroiev, author of a double, and Akbar Usmonov.
The Moroccan and Uzbek selections will meet on Sunday for a second friendly game, again in Maâmoura. This double confrontation serves as a preparation for the next deadlines.