Tarek Sektioui men dominated the meeting from start to finish, having more than 70% of the possession.
Hamza Regragui opened the scoring for The Oranges after 12 minutes, while veteran Mohssine Iajour doubled the lead just before the break after dribbling past Zambian defenders and scoring a beauty.
RS Berkane tops group B on goal difference from Algeria's JS Kabylie, who defeated Cameroon's Coton Sport 1-0 in Tizi Ouzou.
In group D, Raja Casablanca started its campaign with a narrow home win (1-0) over Tanzania’s Namungo.